With regard to HLA-DR expression in T-cells, we found that the TB+HIV+ group displayed a significantly higher percentage of CD4+ cells expressing HLA-DR (median 41.2% [IQR: 19.0–59.2]) as compared with the TB–HIV– (p < 0.001) and TB+HIV– groups (p < 0.001) (Figure 3C). This evidence concerns the gene CD4 and tuberculosis.