Finally, the percentage of CD8+ T-cells expressing HLA-DR was significantly higher in the TB+HIV+ group (median 66.2% [IQR: 61.2–79.9]) than in the TB–HIV+ group (median 45.8% [IQR: 32.6–64.9]) (p = 0.006) as well as both HIV-seronegative groups (Figure 3D). The gene discussed is CD8A; the disease is tuberculosis.