Patients with WS show an increasedDNA methylation age with an averageof 6.4 years. WRN interacts withmethylation complex consisting ofSUV39H1, HP1α, and LAP2β, which isresponsible for the epigenetic histonemark H3K9 trimethylation (H3K9me3). Inresponse to DNA damage, WRN recruitschromatin assembly factor 1 (CAF-1) toalter chromatin structure. Here, WRN is linked to Werner syndrome.