As shown in Fig. 4b, the expression of nrdD during infection was significantly higher in all strains analyzed (PAO1, PA14 and the clinical isolate PAET1) when the promoter contained the C > T modification (pETS196-T; PnrdD (C > T)) than when it had the native PAO1 sequence (pETS136-C (PnrdD)). The gene discussed is SMOX; the disease is infection.