MYC and colorectal carcinoma: The growth arrest phenotype did not ensue when the expression of c-MYC, a target of the Wnt pathway in colorectal cancer (CRC) cells in vitro14 and in normal crypts in vivo37, was artificially maintained during Wnt pathway inhibition, suggesting that c-MYC played a crucial role downstream of the Wnt cascade in maintaining the proliferative status of CRC cell38.