MYC and neoplasm: The main mechanisms by which PIM kinases exert their oncogenic activities include: modulation of MYC transcriptional activity (PIMs phosphorylate MYC on S62 and S329, which results in increased MYC protein stability and thereby transcriptional activity), regulation of cap-dependent translation, regulation of cell cycle progression, and pro-survival signaling counteracting the increased sensitivity of tumor cells to apoptosis3.