To further demonstrate the tumour suppressor function of miR-302b through targeting of Runx2, an miR-302b mimic (miR-302b) or miR-ctrl and a Runx2 over-expression vector (Runx2) or a negative control vector (Runx2-ctrl) were co-transfected into 143B cells. This evidence concerns the gene RUNX2 and neoplasm.