HGS and liver cancer: We found that CDH1 expression was significantly and consistently downregulated in liver cancer specimens compared to non-tumor specimens in GSE25097 (Fig. 6A; P < 0.001), GSE14520 (Fig. 6B; P < 0.001) and GSE36376 (Fig. 6C; P < 0.001), while HGS expression was significantly and consistently upregulated in liver cancer specimens compared to non-tumor specimens in GSE25097 (Fig. 6D; P < 0.001), GSE14520 (Fig. 6E; P < 0.001) and GSE36376 (Fig. 6F; P < 0.001).