Among the top 18 probesets identified based on DEFB1 expression, we found that 16 of them, including CDH1, COMT, DCN, LUM, HSD17B2, UGP2, CYFIP2, AFM, TPD52L1, HPX, STARD5, EPHA3, SRPX, HGS, PDGFRA, RRAGD and FMO3, were consistently differentially expressed in liver cancer and non-tumor specimens. The gene discussed is HSD17B2; the disease is neoplasm.