APP and Cognitive impairment: In addition, we also define the role of cis P-tau in the development and treatment of other short-term and long-term consequences of TBI, including a wide array of CTE-like neurodegenerative features, such as axonal pathology, tau, APP, and TDP-43 pathologies, neuroinflammation, neuronal loss, white matter degeneration and cerebellar pathology, as well as clinically relevant functional deficits, including sensorimotor coordination imbalance, urinary incontinence, and cognitive impairment.