MAPT and Alzheimer disease: However, as documented by well-established antibodies, none of these acute TBI samples had obvious tau oligomers (as detected by oligomeric tau antibody T22), early tau tangles (AT8 antibody), late tau tangles (AT100 antibody), amyloid beta peptide aggregation (Aβ antibody), or TDP-43 pathologies (TDP-43 antibody) in the cortex or hippocampus (Fig. 1e, f, Supplementary Table 1), in contrast to CTE and AD brains where cis P-tau partially co-localized with T22 and AT100 (Fig. 1g, h).