In addition, we also define the role of cis P-tau in the development and treatment of other short-term and long-term consequences of TBI, including a wide array of CTE-like neurodegenerative features, such as axonal pathology, tau, APP, and TDP-43 pathologies, neuroinflammation, neuronal loss, white matter degeneration and cerebellar pathology, as well as clinically relevant functional deficits, including sensorimotor coordination imbalance, urinary incontinence, and cognitive impairment. Here, TARDBP is linked to Cognitive impairment.