A human hepatoma cell line (Hep-G2) that highly expresses the asialoglycoprotein receptor (ASGPr, selective for Gal) and two control cell lines (human cervical cancer (HeLa) and human lung cancer (A549)) without ASGPr expression were used (Supplementary Fig. 6d)40, 41. Here, ASGR1 is linked to hepatocellular carcinoma.