Specifically, we would achieve 90% power to detect associations to NRXN1 (combined AF = 0.022, OR = 2.4) with ~600 cases, to HTR2A (combined AF = 0.03, OR = 1.56) with ~700 cases; to REEP3 (combined AF = 0.04, OR = 2.11) with ~200 cases, and to rare (AF < 0.01) variants in CTTNBP2 (combined AF = 0.003, OR = 4.7) with ~500 cases. This evidence concerns the gene NRXN1 and atrial fibrillation.