The five genes most strongly implicated in canine CD and murine-compulsive grooming (CDH2, CTNNA2, ATXN1, PGCP, and Sapap3) have significantly lower p-values than the other 603 sequenced genes (Wilcoxon unpaired, one-sided p = 2.6 × 10−4). The gene discussed is CDH2; the disease is Cowden disease.