Administration of ESN364 throughout the follicularphase in intact nonhuman primates inhibited estradiol secretion, with no LH surge orsubsequent rise in serum progesterone level (19).Similarly, the NK3Ra MLE4901 (formerly known as AZD4901) resulted in a decrease in LHconcentrations with a reduction in LH pulse frequency in healthy women during estrogenadministration (20) and in women with polycysticovary syndrome (PCOS) (21). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.