Supporting our model, a transgenic mouse model of WT based on induction of Lin28 into nephrogenic lineage (wt1/six2) cells of the intermediate mesoderm generated triphasic WT, but no tumours were formed with induction of the Lin28 transgene in more differentiated cell types such as the cap mesenchyme, ureteric bud, or stroma [56]. Here, LIN28A is linked to neoplasm.