TNFRSF1A and cancer: In addition, as Tnfr1-/-Sharpincpdm/cpdm mice have a considerably longer life span than Sharpincpdm/cpdm mice, which need to be sacrificed by 8 weeks due to severe skin inflammation, these double knock out mice provide means to address whether SHARPIN has important functions later in development and in the development of diseases, such as cancer.