TNF and skin disorder: Importantly, crosses between Sharpincpdm/cpdm mice and Tnf-/- (Tnftm1Jods) or Tnfr1-/- (Tnfrsf1atm1Imx) mice almost fully rescue the inflammatory and dermatitis phenotypes of Sharpincpdm/cpdm mice [6,16,17], although other phenotypes were not rescued, such as abnormal leukocyte cell count, the absence of Peyer’s patches and absence of marginal zones in spleen [6,16].