CCR5 and scleroderma: Of significant interest amongst the highly regulated proinflammatory genes are Ccl5 and one of its receptors of greatest affinity, Ccr5. These genes are of interest in this context due to the fact that their upregulation is associated with chronic inflammation and fibrogenic diseases such as scleroderma [42], pulmonary sarcoidosis [43], and chronic liver disease [44].