Finally, gene USP44, which showed associations with the 46 traits (p-value ≤ 3.49 × 10−14), HsCRP (p-value ≤ 1.81 × 10−31) and HOMA-IR (p-value ≤ 7.75 × 10−11), has been reported to associate with congenital heart disease [82], the increment of the HsCRP in congenital heart disease patient and insulin resistance [83]. The gene discussed is USP44; the disease is congenital heart disease.