DOCK7, which presented associations with the 46 traits (p-value ≤ 4.42 × 10−57), HsCRP (p-value ≤ 3.66 × 10−53) and BMI (p-value ≤ 9.36 × 10−7), has been associated with heart disease and ischemic stroke [76] and overweight and obesity[77]. The gene discussed is DOCK7; the disease is obesity due to melanocortin 4 receptor deficiency.