LEF1 and heart failure: LEF1, which was associated with the 46 traits (p-value ≤ 7.44 × 10−83), has been related to insulin resistance [70] (the analysis demonstrated an association with HOMA-B with p-value ≤ 7.17 × 10−52) and heart failure [71–73] (the analysis showed an association with HsCRP with p-value ≤ 1.22 × 10−122 and Homocysteine with p-value ≤ 2.24 × 10−14).