METAP2, which showed strong association with the 46 traits (p-value ≤ 2.62 × 10−20), HOMA-B (p-value ≤ 3.14 × 10−32), HOMA-IR (p-value ≤ 3.17 × 10−17) and insulin (p-value ≤ 8.61 × 10−10), has demonstrated associations with insulin resistance and insulin levels [79]. Here, METAP2 is linked to Insulin resistance.