Gene GRN, which presented associations with the 46 traits (p-value ≤ 1.63 × 10−16), HOMA-IR (p-value ≤ 2.28 × 10−29) and insulin (p-value ≤ 7.89 × 10−10), has been reported to associate with insulin resistance in type 2 diabetes patients [80] and the blood insulin levels [81]. The gene discussed is INS; the disease is type 2 diabetes mellitus.