NFKB1 and neoplasm: The mechanism by which triterpene glycosides exhibit anticancer activity primarily involve induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at S or G2/M phases and increase of the sub-G0/G1 cell population; regulation of nuclear factor NF-κB expression; reduction in cancer cell adhesion; suppression of cell migration and tube formation; suppression of angiogenesis; inhibition of cell proliferation, colony formation, and tumor invasion [141].