However, analysis of uninfected and infected ME tissue of the C3H/HeJ mouse model of COM found that AQP2 expression was higher, by 3.22 ± 0.47-fold and 2.79 ± 0.57-fold, respectively, than in ME tissue of control BLAB/c mice [36], suggesting that AQP2 upregulation in ME tissue may be unrelated to infection. This evidence concerns the gene AQP2 and infection.