JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: WP1130 prevents deubiquitination of a subset of kinases, such as Bcr-Abl in chronic myelogenous leukemia (CML), Janus-activated kinase 2 (Jak2), and autophagy-initiating kinase ULK1, resulting in their translocation to the aggresome, thus, failing to participate in signal transduction [61–63].