USP1 and non-small cell lung carcinoma: Regarding inhibitors of USPs, GW7647 and pimozide non-competitively inhibited USP1 with inhibition constants (Ki) of 0.7 and 0.5 μM, respectively; inhibiting cellular USP1 activity by these agents sensitized human cisplatin-resistant non-small cell lung cancer cells to cisplatin [21].