Yang et al. studied the function of PMS on macrophage-derived foam cell functions and found that PMS could reduce the high production of intercellular adhesion molecule- (ICAM-) 1 protein and the vascular endothelial growth factor (VEGF) protein levels in the medium induced by oxidized lipoprotein when analyzed by flow cytometry, suggesting that PMS is a powerful agent against atherosclerosis and that PMS action could possibly be through the inhibition of the production of ICAM-1 and VEGF in foam cells [30]. The gene discussed is ICAM1; the disease is atherosclerosis.