Table 1 shows the main miRNA dysregulations found in thyroid tumors, together with their documented associations with oncogenic mutations and their validated molecular targets. Among the latter, a functional role in oncogenic transformation of thyroid cancer cells is played by proto-oncogene receptor tyrosine kinase (KIT), C-X-C motif chemokine ligand 12 (CXCL12), connective tissue growth factor (CTGF), NF-kB, programmed cell death 4 (PDCD4), and yes-associated protein (YAP) (see Table 1), all involved in the regulation of cell proliferation, migration, invasion, and survival. This evidence concerns the gene CCN2 and thyroid cancer.