However, a subsequent analysis of these cells showed that SLE patients indeed exhibit an increased proportion of CD4+NKG2D+CD69+LAP+IL-10+Foxp3− Treg lymphocytes; however, we did not detect a significant association between the levels of these cells with disease activity or other clinical or laboratory parameters. The gene discussed is TGFB1; the disease is systemic lupus erythematosus.