Fandy and collaborators studied the methylation patterns of p15INK4B (cyclin-dependent kinase inhibitor 2B), a cell growth regulator; CDH-1 (cadherin 1), a calcium-dependent cell-cell adhesion molecule; DAPK-1 (death-associated protein kinase 1), a positive mediator of gamma interferon-induced programmed cell death; and SOCS-1 (suppressor of cytokine signaling 1), which acts downstream of cytokine receptors participating in the negative feedback of cytokine signaling, in the bone marrow of 30 patients with MDS or AML. Here, CDH1 is linked to acute myeloid leukemia.