TET2 and hematologic disorder: Several studies have already identified mutations in genes that encode crucial epigenetic regulators of gene transcription, such as IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2), both of which catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate, TET2 (ten eleven translocation 2) which is an α-ketoglutarate-dependent dioxygenase involved in the conversion of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and DNMT3A, all of which have been described in hematological malignancies [11–16].