SOCS1 and acute myeloid leukemia: Fandy and collaborators studied the methylation patterns of p15INK4B (cyclin-dependent kinase inhibitor 2B), a cell growth regulator; CDH-1 (cadherin 1), a calcium-dependent cell-cell adhesion molecule; DAPK-1 (death-associated protein kinase 1), a positive mediator of gamma interferon-induced programmed cell death; and SOCS-1 (suppressor of cytokine signaling 1), which acts downstream of cytokine receptors participating in the negative feedback of cytokine signaling, in the bone marrow of 30 patients with MDS or AML.