CDKN2A and urinary bladder cancer: Several studies have evaluated methylation of multiple tumour suppressor genes to determine their relationship with bladder cancer tissue and subsequent methylation status in urine, and some of these genes include APC, ARF, BAX, BCL2, CDH1, CDKN2A, DAPK, EDNRB, EOMES, FADD, GDF15, GSTP1, LITAF, MGMT, NID2, PCDH17, POU4F2, RARβ2, RASSF1A, TCF21, TERT, TIMP3, TMS-1, TNFRSF21, TNFRSF25, and ZNF154 [24, 45, 58].