To determine the effects of OSM and IL-6 on bleomycin-induced lung fibrosis, wild-type C57BL/6 mice were intratracheally administered adenovirus control vector or adenovirus encoding OSM or IL-6 to induce transient overexpression of OSM or IL-6, alone or in combination with bleomycin (0.03U/mouse). The gene discussed is IL6; the disease is pulmonary fibrosis.