In addition, the Pkinase domain of AKT1 in BLCA, DSPc domain of PTEN in CCRCC, Pkinase_Tyr domain of ERBB4 in EGC, DSPc domain of PTEN in ENDO, PI3Ka domain of PIK3CA in HNC, Pkinase_Tyr domain of ERBB2 in IDC, Pkinase_Tyr domain of EGFR in NSCLC, and P53 domain of TP53 in OC were also detected to be significantly associated with metastasis. The gene discussed is EGFR; the disease is bladder transitional cell carcinoma.