We detected significantly altered protein-domain pairs in ten cancer types, in which the p53 domain of TP53 in PRAD (p = 0.00011), Iso_dh domain of IDH1 (p = 0.00022) and Gly_rich domain of ALK (p = 0.00074) in Glioma were the most significantly altered. This evidence concerns the gene TP53 and cancer.