In addition, the Pkinase domain of AKT1 in BLCA, DSPc domain of PTEN in CCRCC, Pkinase_Tyr domain of ERBB4 in EGC, DSPc domain of PTEN in ENDO, PI3Ka domain of PIK3CA in HNC, Pkinase_Tyr domain of ERBB2 in IDC, Pkinase_Tyr domain of EGFR in NSCLC, and P53 domain of TP53 in OC were also detected to be significantly associated with metastasis. This evidence concerns the gene PIK3CA and bladder transitional cell carcinoma.