Among these genes with significantly altered copy numbers between primary and metastatic cancers, it was noted that the copy number of CDKN2A/B was decreased in metastatic cancer in TC, PAAD and NSCLC but increased in SKCM and Glioma, suggesting that the role of CDKN2A/B is different in the metastasis in cancers. This evidence concerns the gene CDKN2A and central nervous system cancer.