With reference to liver cytokine milieu, IL-10 levels showed an inverse relation with fibrosis severity (significant fibrosis p = 0.0398, advanced fibrosis p = 0.0291) whereas TNF-α and TGF-β were associated with hepatitis severity (p = 0.0409, p = 0.0321; respectively) (Fig. 3). This evidence concerns the gene TNF and hepatitis A virus infection.