However, Tregs role in CHC are still a matter of debate, since Sturm et al. 29 reported positive correlation between intrahepatic CD4+-Foxp3+ frequency and fibrosis severity, and Langhans et al. 30 described positive correlation of IL-8+-Foxp3+-CD4+ lymphocytes with worse fibrosis. This evidence concerns the gene FOXP3 and cryohydrocytosis.