Given that the genetic background of our luc mice (C57BL/6NJ) is different than the Zdhhc13 (Hip14l) KO mice utilized by Dr. Hayden’s group (FVB/N)5 and that genetic background affects the appearance of phenotypes even when carrying the same mutations16, behavioral tests (including those representative of the HD’s phenotype) were administered to both HOM and HET mice (3-m old). This evidence concerns the gene ZDHHC13 and Huntington disease.