SLC25A22 and nervous system disorder: Although we cannot completely exclude the role of other S-palmitoylated proteins (e.g., mitochondrial glutamate carrier 1) as well as other brain regions not tested in this study, S-palmitoylation of Drp1, acting alone or in concert (Supplementary Table S2), constitutes a novel regulation that has the potential to serve as a springboard to develop strategies for generating therapies not only for neurological disorders with energy deficits and/or neurotransmitter imbalances.