In the lung cancer cells, previous studies also indicated that store-operated calcium entry is involved in COX-2 gene activation as well as cell cycle progression29,49 We suspect that after the cell’s initial exposure to LPS, inositol 1,4,5-trisphosphate receptor (IP3R) was activated by IP3, and quickly depleted ER calcium store. This evidence concerns the gene ITPR1 and lung cancer.