Similar with that of HCT116, MIIP S303A expression which blocked promoter-enrichment of MIIP (Supplementary Fig. 4d) or RelA Ac-K310 in CaCo2 cells (Supplementary Fig. 4e), inhibited transcription of MMP2 and Twist (Supplementary Fig. 4f) and tumor cell invasion (Supplementary Fig. 4g). This evidence concerns the gene RELA and neoplasm.