EGF and neoplasm: Apparently, immunoblotting analysis showed the EGF stimulated stronger MIIP-S303 phosphorylation in CRC cells (Supplementary Fig. 3a) which displayed the higher tendency of invasion (Supplementary Fig. 3b), implying there would be certain cellular component that counteracts PKCε-mediated MIIP phosphoryaltion and restricts invasive ability of tumor cells.