Previous studies indicated MIIP antagonizes insulin-like growth factor binding protein 2 (IGFBP-2)-mediated invasion in glioma cell15, and is able to inhibit the enzymatic activity of Histone deacetylase 6 (HDAC6) against α-tubulin acetylation that is related to reduction of cell migration16. This evidence concerns the gene IGFBP2 and central nervous system cancer.