In accordance, immunoblotting analysis of mice tumor tissues indicated WT rMIIP but not rMIIP S303A underwent S303 phosphorylation during tumor growth, and RelA Ac-K310 levels was attenuated in tumor tissues from cells with rMIIP S303A expression in a HDAC6 dependent manner (Fig. 6b). This evidence concerns the gene HDAC6 and neoplasm.