To clarify whether the regulation of RelA by MIIP is dependent on KRAS status, endogenous MIIP was depleted and the expression of RNAi resistant WT rMIIP and rMIIP S303A were reconstituted in the colon cancer cell line CaCo2 cells (Supplementary Fig. 4b), which express wild type-KRAS. The gene discussed is RELA; the disease is malignant colon neoplasm.