MMP2 and neoplasm: Similar with that of HCT116, MIIP S303A expression which blocked promoter-enrichment of MIIP (Supplementary Fig. 4d) or RelA Ac-K310 in CaCo2 cells (Supplementary Fig. 4e), inhibited transcription of MMP2 and Twist (Supplementary Fig. 4f) and tumor cell invasion (Supplementary Fig. 4g).