Interestingly, despite being protected from E. faecalis -exacerbated alcoholic liver disease, chimeric mice with Kupffer cells that did not express MYD88/TRIF had a significantly higher percentage of positive Enterococcus blood cultures than mice with WT or Tlr2−/− Kupffer cells (Supplementary Fig. 7c). The gene discussed is TICAM1; the disease is alcoholic liver diseases.