Other chemokines may exert such a pro-angiogenic effect: MCP-1/CCL2 is the first CC chemokine reported to play a direct role in tumor angiogenesis52, eotaxin also induces in vivo angiogenic responses by using endothelial cells expressing CCR353 and numerous studies highlighted the role of CXCL4 in angiogenesis54. Here, CCL2 is linked to neoplasm.