NFKB1 and allergic contact dermatitis: It has been also reported that SR inhibits the production of inflammatory cytokines in lipopolysaccharide-activated Raw 264.7 cells, decreases the symptoms of 2,4-dinitrochlorobenzene-induced allergic contact dermatitis in mice, and suppresses hypoxia-induced neurotoxicity by scavenging hypoxia-induced inflammatory cytokines, inhibiting the activation of NF-κB, and reducing HIF-1α generation in microglial cells14.