In line with these results, knockout (KO) of TRIM29 by CRISPR/Cas9 strategy also enhanced production of IFN-α and IFN-β in both, BEAS-2B and CNE1 cells, in response to intracellular VACV-70, poly(dG:dC) or EBV infection, and EBV viral loads were lower in TRIM29 KO cells than in control cells (Supplementary Fig. 2). Here, IFNB1 is linked to Epstein-Barr virus infection.