Similarly, compared with WT cells, Trim29-KO BMDMs produced twofold to fivefold more IFN-β and IFN-α in response to HSV-1 or adenovirus infection than did WT BMDMs at 6, 12, or 20 h post infection (Supplementary Figs. 6b and 7). This evidence concerns the gene TRIM29 and infection.