MAPT and dementia: 2010). The pathophysiology of this dysregulation is unknown, but may involve altered function of central pathways involved in the baroreflex. For example, CSH is common in patients with dementia with Lewy bodies, which points to central white matter lesions as contributors to the large heart rate and systolic blood pressure responses to CSM (Kenny et al. 2004). In patients with CSH, increased tau accumulation in baroreflex‐associated nuclei has been observed (Miller et al. 2008), but cause and effect in terms of CSH has yet to be demonstrated.