CD4 and obesity due to melanocortin 4 receptor deficiency: 2007). Moreover, in macaques with simian immunodeficiency virus (SIV) compared to uninfected controls, biopsies of SAT and VAT demonstrated a greater CD8+/CD4+ T‐cell ratio and increased expression of T‐cell activation markers (Damouche et al. 2015). Given that this inflammatory profile resembles that seen in obesity (Nishimura et al. 2009), individuals with HIV‐related SAT inflammation may be short‐circuited toward complications of excess adiposity at a lower BMI.