We therefore stimulated foetal testis cells with cAMP and indeed found moderate increase in expressions of GATA3, 4 and 6. The ACTH receptor (MC2R) signals via cAMP and elevated ACTH levels are present in CAH patients and associated with the development of TARTs (25, 26, 27). The gene discussed is GATA3; the disease is congenital adrenal hyperplasia.