Although there are shared molecular mechanisms between the recycling of integrin and TfnR, there are also integrin-specific regulators that provide spatial and temporal control of adhesion receptor availability at the PM: for example, in carcinoma cells, Rab-coupling protein, a member of the Rab11-family interacting proteins, has a crucial role in regulating integrin recycling but is dispensable for TfnR recycling (Muller et al., 2009). The gene discussed is RAB11FIP1; the disease is carcinoma.