VCP and amyotrophic lateral sclerosis: Mutations in VCP are causative of two fatal proteinopathies: amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD) (Watts et al., 2004, Johnson et al., 2010, Abramzon et al., 2012).