Mutations in VCP are causative of two fatal proteinopathies: amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD) (Watts et al., 2004, Johnson et al., 2010, Abramzon et al., 2012). The gene discussed is VCP; the disease is inclusion body myopathy with Paget disease of bone and frontotemporal dementia.