M2 TAMs promote angiogenesis by producing IL-10 and CCL22, induce immune-suppression by inhibiting NK cells, T cells, and DCs by arginine deprivation through arginase expression, facilitate invasion by remodeling the stroma through matrix metalloproteases, and increase metastatic tumor cell shedding through abnormal tumor vasculature [12, 128], all of which are important factors for metastasis. This evidence concerns the gene CCL22 and neoplasm.