KCNN4 and ischemic stroke: In order to study the role of KCa3.1 deficiency on the pathological processes of ischemic stroke, we subjected wild type (WT) and KCa3.1 gene deletion (KCa3.1−/−) mice to 3, 6, and 24 h of pMCAO and assessed infarct volumes and neurological deficits (Fig. 2).