BRAF and colorectal carcinoma: Of these 75 patients, none had RAS mutations; 71 had BRAF V600E mutations, 2 had BRAF K601E mutations that had been previously found in CRC cases [8], 1 had a D594G mutation, and 1 had an AGA insertion between BRAF codons 599 and 600 (T599_V600insAGA alteration) that was not previously registered in the COSMIC database (http://cancer.sanger.ac.uk/cosmic) [8].