Quantitative RT-PCR analysis of B6 and hTau brains revealed a significant upregulation of Trem2 transcripts in 12-month hTau mice compared to other experimental groups, consistent with a disease state dependent role for TREM2 in regulating tau pathology (Fig. 3b), analogous to that observed with amyloid pathology [28]. Here, MAPT is linked to amyloidosis.