Although the controls were not healthy subjects and the sample size was small, the results showed that EAT SFRP4 expression was significantly increased in CAD patients, and CAD is an independent predictor of SFRP4 elevation, indicating that SFRP4 elevation is attributed to the onset of CAD, and participates in the development of CAD via modulation of the Wnt pathway. The gene discussed is SFRP4; the disease is coronary artery disorder.