INS and coronary artery disorder: In contrast, as seen in Table 3, SAT-derived SFRP4 mRNA levels were not associated with CAD (P = 0.086) but were found to be positively associated with fasting insulin in a multivariate linear regression model adjusted for age, BMI and CAD (beta = 0.382, 95% CI 0.008–0.756; P = 0.045).