NOX2 might play a role in myofibroblast differentiation, as a recent study found that oxidants produced by NOX2 mediate α-SMA and ECM upregulation in human dermal fibroblasts in response to TGFβ1 [128] Recently, the role of NOX4 in bleomycin-induced pulmonary fibrosis has been investigated [129]. The gene discussed is CYBB; the disease is pulmonary fibrosis.