In GHD children, it has been observed that the lower the IGF-1 bioavailability index obtained from the IGF-1/IGFBP-3 ratio, the higher the adiponectin levels, when compared to GHD children with a high index; moreover, the lower IGF-1 bioavailability index was characterized by lower insulin resistance [70]. Here, IGF1 is linked to Insulin resistance.