As for GHD, in adult patients, under replacement GH therapy, a variety of different conditions have been recorded: some studies show that serum adiponectin levels and insulin resistance are not affected [63,64], others describe unchanged adiponectin values and reduced [65,66] or increased insulin resistance [67], and others report an increase in adiponectin with reduced [68] or unchanged insulin resistance [69]. The gene discussed is GH1; the disease is Insulin resistance.