A formulation encapsulating docetaxel and VEGF siRNA conjugated with two different targeting peptides angiopep-2 and neuropilin demonstrated the most efficient uptake in vivo at an optimized conjugation ratio thereby showing a dual approach which assisted translocation with almost 20% higher VEGF silencing than controls in a U87 MG tumor-bearing mouse model [145]. The gene discussed is VEGFA; the disease is neoplasm.