Indeed, increased levels of phosphorylated PERK (p-PERK) and phosphorylated eIF2α (p-eIF2α) have been found in several neurodegenerative diseases and models, such as Alzheimer’s disease (AD) (9), Parkinson’s disease (10), amyotrophic lateral disease (ALS) (11) and prion diseases (12) directing future studies on manipulation of the PERK branch. Here, EIF2AK3 is linked to prion disease.