Indeed, increased levels of phosphorylated PERK (p-PERK) and phosphorylated eIF2α (p-eIF2α) have been found in several neurodegenerative diseases and models, such as Alzheimer’s disease (AD) (9), Parkinson’s disease (10), amyotrophic lateral disease (ALS) (11) and prion diseases (12) directing future studies on manipulation of the PERK branch. This evidence concerns the gene EIF2A and prion disease.