Indeed, increased levels of phosphorylated PERK (p-PERK) and phosphorylated eIF2α (p-eIF2α) have been found in several neurodegenerative diseases and models, such as Alzheimer’s disease (AD) (9), Parkinson’s disease (10), amyotrophic lateral disease (ALS) (11) and prion diseases (12) directing future studies on manipulation of the PERK branch. The gene discussed is EIF2A; the disease is early-onset autosomal dominant Alzheimer disease.