Moreover, it has been suggested that the causal link between severe HRSV infection at an early age and recurrent wheeze [36] and the increased risk of developing asthma and atopy later in life in these individuals [37, 38] can be explained by a genetic predisposition for neutrophil recruitment and activity, through increased IL-8 and decreased IL-10 responses to infection [2, 39, 40]. Here, CXCL8 is linked to infection.