Due to its heterogeneous nature, MG is in addition to age at onset, sub classified according to clinical presentation (ocular MG vs generalised MG), thymus histopathology (thymoma, thymus hyperplasia) and autoantibody (ab) profile (acetylcholine receptor (AChR) ab, muscle-specific kinase (MuSK) ab, lipoprotein receptor-related protein 4 (Lrp4) ab) [2]. This evidence concerns the gene LRP4 and myasthenia gravis.