To our knowledge, no studies have been published so far on the association between helminth infections and adipokines, except for resistin.18 Therefore, we measured leptin, adiponectin, and resistin in serum samples obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminth (STH).19 We hypothesized that the increase in IR after anthelmintic treatment in helminth-infected subjects might be mediated by a shift in L/A ratio towards a more pro-inflammatory state. The gene discussed is RETN; the disease is helminthiasis.